Abstract Search

ea0090oc7.2 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2023

BRF1-Mediated Paracrine Signalling by a Subset of SOX2-Expressing Stem Cells is required for Normal Development of the Stem Cell Compartment and Terminal Differentiation of Pituitary Committed Progenitors

Martinez-Barbera Juan Pedro , Manshaei Saba , Willis Thea , Reen Virinder , Pallikonda Hussayn , Withers Dominic , Gil Jesus , Andoniadou Cynthia

Introduction: Hormone-producing pituitary cell lineages derive from SOX2+ embryonic precursors. These cells maintain multipotency into early postnatal life, acting as the resident population of pituitary stem cells (PSCs) and contributing extensively to all the endocrine cell lineages. Additionally, paracrine signalling from PSCs is important for cell proliferation of neighbouring progenitors (PMC7803373). It is not known if SOX2+ PSCs are involved in the regulation of additio...

0 shares

Endocrine Abstracts

BRF1-Mediated Paracrine Signalling by a Subset of SOX2-Expressing Stem Cells is required for Normal Development of the Stem Cell Compartment and Terminal Differentiation of Pituitary Committed Progenitors

BiosciAbstracts